Some aspects of lipid metabolism in rats treated with anti-insulin serum.

نویسندگان

  • M E TARRANT
  • R H THOMPSON
  • P H WRIGHT
چکیده

Rats can be made diabetic by pancreatectomy (Scow, 1957) or by the administration of alloxan (Lukens, 1948) or of anti-insulin serum (Armin, Grant & Wright, 1960b). Some of the metabolic abnormalities in pancreatectomized (Scow & Chernick, 1960) and alloxan-diabetic (Lukens, 1948; Spiro & Hastings, 1958) rats have been studied, but little is known about the serum-treated animals. The observations reported here show that lipid accumulates rapidly in the liver and blood of rats rendered diabetic by anti-insulin serum.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effect of Linalool on the Activity of Glyoxalase-I and Diverse Glycation Products in Rats with Type 2 Diabetes

Background and purpose: Hyperglycemia contributes to type 2 diabetes and diabetes vascular complications by reduction of the activity of glyoxalase-I (GLO-I) and elevation of glycation, oxidative stress, and inflammatory markers. Linalool is reported to have beneficial effects on glucose metabolism in animal models of diabetes, so, this study aimed at investigating the effect of linalool on the...

متن کامل

The anti-diabetic potential of P-Cymene monoterpene on serum factor levels and SOD assay in STZ-diabetic male rats

Diabetes is a serious public health problem in low- and middle-income countries. There is a strong association between hyperglycemia, oxidative stress and the development of diabetes. Therefore, screening and early diagnosis of this disease in people at high risk can be effective in preventing these complications. The main route of insulin signaling is to control lipid and glucose metabolism, a...

متن کامل

Evaluation of Serum Vaspin and Chemerin Levels in Type 2 Diabetic and Treated with Anti Diabetic Drugs Metformin and Acarbose in Rats

  Background & Objective: The serum levels of adipose tissue hormons, Vaspin and Chemerin, alter in some disorder conditions such as diabetes. The aim of this study is to investigate the effect of two anti-diabetic drugs (Metformin and Acarbose) and their combination on serum concentration of Vaspin and Chemerin in type 2 diabetic rats.   Materials & Methods: 30 male, wistar rats are randomly d...

متن کامل

The effect of adropin on lipid and glucose metabolism in rats with hyperlipidemia

Objective(s):The aim of this study was to evaluate, for the first time, whether the effects of low-dose adropin administration is effective in rats with hyperlipidemia. Materials and Methods: Twenty one Wistar albino female rats were randomly divided into 3 groups and fed with high-fat diet for 4 weeks to establish the hyperlipidemia model. Meanwhile, adropin was administrated intraperitonealy...

متن کامل

Anti-diabetic effect of Capparis spinosa L. root extract in diabetic rats

Objective: Diabetes mellitus is the most common metabolic disorders with severe impact on quality of life. Reducing serum glucose levels and normalization of serum lipid is of great clinical importance for treating diabetes. To our knowledge, there are not any evidences about the anti-diabetic action of capparis spinosa root. In the present study the effects of the C. spinosa root extract on di...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The Biochemical journal

دوره 84  شماره 

صفحات  -

تاریخ انتشار 1962